In this blog post, we’ll explore why the human body is not fully regenerative and whether animal testing has the potential to overcome this limitation.
Humans are unable to regenerate parts like fingers or noses that are cut off in accidents. This physical loss is not just a cosmetic issue; it leads to functional impairment, causing great inconvenience in daily life. What’s more, these losses can also have an emotional impact, leading many people to feel socially isolated or depressed. For people who have lost a part of their body, there is an urgent need for a way to restore it. However, today’s medical technology lacks the ability to fully address this.
Many people with terminal illnesses are dying because they can’t get the organs they need in time. Currently, there is no good way to solve this problem. The waiting list for organ transplants grows longer every year, causing families and patients to spend time in despair and anxiety. The medical community is working to advance artificial organs and bio-printing technologies, but there are still many technical and ethical issues that prevent them from being widely available. But there are chemical engineers working to give these people hope.
Charles Vacanti, director of the MIT Medical Center, and a group of chemical engineers are working to create human ears by inserting bovine cartilage cells into the bodies of mice. The cartilage that makes up the ear has no way to be repaired if it loses its shape, either congenitally or acquired. That’s why Charles Vacanti and others are trying to grow ear-shaped cells in the backs of mice. This research is more than just a scientific curiosity, it’s considered a major breakthrough that could have a significant impact on future medical technology. This is because if successful, it could open up the possibility of repairing other parts or organs in the human body in a similar way. These mice are called vacanti mice.
In the process of creating the ears, engineers use nude mice. A normal mouse would reject the injected bovine chondrocytes. On the other hand, nude mice are not only hairless due to a mutation, but also have a very weak immune system. This weak immune system is crucial to the success of the experiment, as it does not reject the externally injected cells. The nude mice also provide space for the bovine chondrocytes to grow and act as a source of energy to support their growth.
Let’s take a closer look at how the experiment works. First, a mold is inserted inside the mouse to help the bovine chondrocytes grow into the shape of an ear. It’s important to note that this mold must be inserted between the rat’s skin and muscle layers. Because the mold is made of a material similar to the threads we usually use in surgery, it breaks down into water and carbon dioxide after a certain amount of time in the body. It also forms a mesh-like structure with 97% of its interior filled with air, which allows the bovine chondrocytes to grow in the empty space occupied by the air. After about three months, the rat’s blood vessels extend to the cow’s chondrocytes and supply them with nutrients. The cells differentiate between the wire mesh, and after the cells have settled into the shape of a complete human ear, the wire mesh is completely biodegradable.
This experiment has not yet been performed on humans. Since it uses bovine cells, there’s no way to transplant them into humans without the immune system rejecting them, and the researchers emphasize the need for thorough safety and effectiveness testing before applying the experiment to humans. This is a very important ethical issue in biotechnology. However, engineers believe that in the not-too-distant future, they will be able to conduct experiments using human cells.
In fact, this technological advancement has the potential to revolutionize our lives. If it becomes possible to repair damaged organs or body parts, it will not only extend human lifespan, but also improve the quality of life. However, ethical barriers remain. One might think that when this technology is commercialized, animals will be treated as mere tools to produce organs. In fact, many different animals are needed to create organs in the body, not just simple parts like ears. Nonetheless, scientists and engineers are proceeding with their research while taking into account the ethical issues of animal testing as much as possible. This is to ensure that scientific advancement is balanced with ethical responsibility. However, the ethical considerations of animal testing are constantly under scrutiny, and without these sacrifices, modern biotechnology would not be where it is today. Of course, we should always be grateful to these animals, but there are countless others who would still be suffering today, thanks to the work of chemical biologists around the world.
